7v6z: Difference between revisions

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<StructureSection load='7v6z' size='340' side='right'caption='[[7v6z]], [[Resolution|resolution]] 3.64&Aring;' scene=''>
<StructureSection load='7v6z' size='340' side='right'caption='[[7v6z]], [[Resolution|resolution]] 3.64&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7v6z]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=7dzp 7dzp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7V6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7V6Z FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7V6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7V6Z FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.64&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7dzp|7dzp]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v6z OCA], [https://pdbe.org/7v6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v6z RCSB], [https://www.ebi.ac.uk/pdbsum/7v6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v6z ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v6z OCA], [https://pdbe.org/7v6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v6z RCSB], [https://www.ebi.ac.uk/pdbsum/7v6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v6z ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/PTC1_MOUSE PTC1_MOUSE]] Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.<ref>PMID:21537345</ref> 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Li, D]]
[[Category: Li D]]
[[Category: Luo, Y]]
[[Category: Luo Y]]
[[Category: Qu, Q]]
[[Category: Qu Q]]
[[Category: Zhao, Y]]
[[Category: Zhao Y]]
[[Category: Caveolae]]
[[Category: Hedgehog signaling]]
[[Category: Lipid nanodisc]]
[[Category: Membrane protein]]
[[Category: Patched]]
[[Category: Ptc1 dimer]]
[[Category: Thermostable mutant]]
Retrieved from "https://proteopedia.org/7v6z"