2l1b: Difference between revisions

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==Solution NMR structure of the chromobox protein Cbx7 with H3K27me3==
==Solution NMR structure of the chromobox protein Cbx7 with H3K27me3==
<StructureSection load='2l1b' size='340' side='right'caption='[[2l1b]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2l1b' size='340' side='right'caption='[[2l1b]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2l1b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L1B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L1B FirstGlance]. <br>
<table><tr><td colspan='2'>[[2l1b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L1B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L1B FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CBX7 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l1b OCA], [https://pdbe.org/2l1b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l1b RCSB], [https://www.ebi.ac.uk/pdbsum/2l1b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l1b ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l1b OCA], [https://pdbe.org/2l1b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l1b RCSB], [https://www.ebi.ac.uk/pdbsum/2l1b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l1b ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/CBX7_HUMAN CBX7_HUMAN]] Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.<ref>PMID:19636380</ref> <ref>PMID:21060834</ref> <ref>PMID:21282530</ref> <ref>PMID:21047797</ref> 
[https://www.uniprot.org/uniprot/Q92133_XENLA Q92133_XENLA]  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l1/2l1b_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l1/2l1b_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C]]
[[Category: Xenopus laevis]]
[[Category: Edwards, A]]
[[Category: Arrowsmith C]]
[[Category: Fares, C]]
[[Category: Edwards A]]
[[Category: Gutmanas, A]]
[[Category: Fares C]]
[[Category: Kaustov, L]]
[[Category: Gutmanas A]]
[[Category: Lemak, A]]
[[Category: Kaustov L]]
[[Category: Loppnau, P]]
[[Category: Lemak A]]
[[Category: Min, J]]
[[Category: Loppnau P]]
[[Category: Muhandiram, R]]
[[Category: Min J]]
[[Category: Quang, H]]
[[Category: Muhandiram R]]
[[Category: Structural genomic]]
[[Category: Quang H]]
[[Category: Chromodomain]]
[[Category: Sgc]]
[[Category: Transcription regulator]]

Latest revision as of 22:25, 26 March 2025

Solution NMR structure of the chromobox protein Cbx7 with H3K27me3

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