3weu: Difference between revisions

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<StructureSection load='3weu' size='340' side='right'caption='[[3weu]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
<StructureSection load='3weu' size='340' side='right'caption='[[3weu]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3weu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Marm1 Marm1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WEU FirstGlance]. <br>
<table><tr><td colspan='2'>[[3weu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Marinomonas_mediterranea_MMB-1 Marinomonas mediterranea MMB-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WEU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=TRQ:2-AMINO-3-(6,7-DIOXO-6,7-DIHYDRO-1H-INDOL-3-YL)-PROPIONIC+ACID'>TRQ</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRQ:2-AMINO-3-(6,7-DIOXO-6,7-DIHYDRO-1H-INDOL-3-YL)-PROPIONIC+ACID'>TRQ</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3wev|3wev]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lodA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=717774 MARM1])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/L-lysine_6-oxidase L-lysine 6-oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.20 1.4.3.20] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3weu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3weu OCA], [https://pdbe.org/3weu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3weu RCSB], [https://www.ebi.ac.uk/pdbsum/3weu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3weu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3weu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3weu OCA], [https://pdbe.org/3weu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3weu RCSB], [https://www.ebi.ac.uk/pdbsum/3weu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3weu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/LODA_MARM1 LODA_MARM1]] Has antibacterial activity against a wide spectrum of Gram-positive and Gram-negative bacteria including nosocomial isolates of S.aureus and Pseudomonas sp. The antimicrobial activity is due to hydrogen peroxide generated by its lysine oxidase activity. Also has autotoxic activity. Involved in biofilm differentiation; responsible for cell death within microcolonies during biofilm development which is linked to the generation of a phenotypically diverse dispersal population and thus may play a role in colonization.<ref>PMID:15652194</ref> <ref>PMID:18502869</ref> <ref>PMID:20025674</ref>
[https://www.uniprot.org/uniprot/LODA_MARM1 LODA_MARM1] Has antibacterial activity against a wide spectrum of Gram-positive and Gram-negative bacteria including nosocomial isolates of S.aureus and Pseudomonas sp. The antimicrobial activity is due to hydrogen peroxide generated by its lysine oxidase activity. Also has autotoxic activity. Involved in biofilm differentiation; responsible for cell death within microcolonies during biofilm development which is linked to the generation of a phenotypically diverse dispersal population and thus may play a role in colonization.<ref>PMID:15652194</ref> <ref>PMID:18502869</ref> <ref>PMID:20025674</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: L-lysine 6-oxidase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Marm1]]
[[Category: Marinomonas mediterranea MMB-1]]
[[Category: Akaji, S]]
[[Category: Akaji S]]
[[Category: Asano, Y]]
[[Category: Asano Y]]
[[Category: Inagaki, K]]
[[Category: Inagaki K]]
[[Category: Matsui, D]]
[[Category: Matsui D]]
[[Category: Nakano, S]]
[[Category: Nakano S]]
[[Category: Okazaki, S]]
[[Category: Okazaki S]]
[[Category: Amine oxidase]]
[[Category: Amino acid oxidase]]
[[Category: Arm]]
[[Category: Beta barrel]]
[[Category: L-lys binding]]
[[Category: Oxidoreductase]]
[[Category: Three beta sheet]]
Retrieved from "https://proteopedia.org/3weu"