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<StructureSection load='7wdb' size='340' side='right'caption='[[7wdb]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='7wdb' size='340' side='right'caption='[[7wdb]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7wdb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WDB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WDB FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WDB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WDB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=657:6-(trifluoromethoxy)-1,3-benzothiazol-2-amine'>657</scene>, <scene name='pdbligand=7OC:[3-[(~{E})-octadec-10-enoyl]oxy-2-oxidanyl-propyl]+(~{E})-octadec-10-enoate'>7OC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=657:6-(trifluoromethoxy)-1,3-benzothiazol-2-amine'>657</scene>, <scene name='pdbligand=7OC:[3-[(~{E})-octadec-10-enoyl]oxy-2-oxidanyl-propyl]+(~{E})-octadec-10-enoate'>7OC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wdb OCA], [https://pdbe.org/7wdb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wdb RCSB], [https://www.ebi.ac.uk/pdbsum/7wdb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wdb ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wdb OCA], [https://pdbe.org/7wdb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wdb RCSB], [https://www.ebi.ac.uk/pdbsum/7wdb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wdb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/TRPC5_HUMAN TRPC5_HUMAN]] Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity).[UniProtKB:Q9QX29]<ref>PMID:16284075</ref>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chen L]]
[[Category: Chen L]]
[[Category: Wei M]]
[[Category: Wei M]]
[[Category: Yang Y]]
[[Category: Yang Y]]

Latest revision as of 23:09, 26 March 2025

Human TRPC5 channel in complex with riluzole

7wdb, resolution 2.40Å

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