6au2: Difference between revisions

<table><tr><td colspan='2'>[[6au2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AU2 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CGJ:1-methyl-4H,6H-[1,2,4]triazolo[4,3-a][4,1]benzoxazepine'>CGJ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6au2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6au2 OCA], [https://pdbe.org/6au2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6au2 RCSB], [https://www.ebi.ac.uk/pdbsum/6au2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6au2 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/SETB1_HUMAN SETB1_HUMAN] Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins.<ref>PMID:12869583</ref> <ref>PMID:14536086</ref> <ref>PMID:15327775</ref> <ref>PMID:17952062</ref>  

[[Category: Homo sapiens]]

[[Category: Arrowsmith CH]]

[[Category: BROWN PJ]]

[[Category: Bountra C]]

[[Category: CORLESS VB]]

[[Category: DELA SENA CC]]

[[Category: DIAZ D]]

[[Category: DOBROVETSKY E]]

[[Category: DONG A]]

[[Category: Edwards AM]]

[[Category: HOLOWNIA A]]

[[Category: IQBAL A]]

[[Category: KENNEDY S]]

[[Category: LIEW SK]]

[[Category: MADER P]]

[[Category: Mendoza-Sanchez R]]

[[Category: SANTHAKUMAR V]]

[[Category: SMIL D]]

[[Category: TEMPEL W]]

[[Category: VEDADI M]]

[[Category: YUDIN AK]]