Sandbox Reserved 1851: Difference between revisions
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==General Structure== | ==General Structure== | ||
===Active Site=== | ===Active Site=== | ||
In the active state, there are two catalytic <scene name='10/1075253/Active_site_residues/6'>residues</scene> that aim to stabilize the transition state of the Diels-Alder reaction. Y134 acts as a hydrogen bond donor to the oxygen on the <scene name='10/1075253/Ligand/2'>ligand</scene>. Q208 acts as a <scene name='10/1075253/Ligand/4'>hydrogen bond acceptor</scene> to the nitrogen on the ligand as well as a donor to the neighboring oxygen. These interactions help reduce the energetic gap between orbitals allowing the reaction to proceed, outlined in HOMO/LUMO. | In the active state, there are two catalytic <scene name='10/1075253/Active_site_residues/6'>residues</scene> that aim to stabilize the transition state of the Diels-Alder reaction. Y134 acts as a <scene name='10/1075253/Ligand/5'>hydrogen bond donor</scene> to the oxygen on the <scene name='10/1075253/Ligand/2'>ligand</scene>. Q208 acts as a <scene name='10/1075253/Ligand/4'>hydrogen bond acceptor</scene> to the nitrogen on the ligand as well as a donor to the neighboring oxygen. These interactions help reduce the energetic gap between orbitals allowing the reaction to proceed, outlined in HOMO/LUMO. | ||
