9ehi: Difference between revisions
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The | ==Crystal structure of ENL YEATS in complex with histone H3 methacrylated at K18== | ||
<StructureSection load='9ehi' size='340' side='right'caption='[[9ehi]], [[Resolution|resolution]] 2.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9ehi]] is a 32 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EHI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EHI FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BIE:N~6~-(2-methylprop-2-enoyl)-L-lysine'>A1BIE</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ehi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ehi OCA], [https://pdbe.org/9ehi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ehi RCSB], [https://www.ebi.ac.uk/pdbsum/9ehi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ehi ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/ENL_HUMAN ENL_HUMAN] A chromosomal aberration involving MLLT1 is associated with acute leukemias. Translocation t(11;19)(q23;p13.3) with KMT2A/MLL1. The result is a rogue activator protein. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ENL_HUMAN ENL_HUMAN] Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.<ref>PMID:20159561</ref> <ref>PMID:20471948</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Becht DC]] | |||
[[Category: Kutateladze TG]] | |||
[[Category: Selvam K]] | |||
Latest revision as of 07:57, 9 April 2025
Crystal structure of ENL YEATS in complex with histone H3 methacrylated at K18
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