2x4w: Difference between revisions

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<StructureSection load='2x4w' size='340' side='right'caption='[[2x4w]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='2x4w' size='340' side='right'caption='[[2x4w]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2x4w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X4W FirstGlance]. <br>
<table><tr><td colspan='2'>[[2x4w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X4W FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2x35|2x35]], [[2d9e|2d9e]], [[2x4y|2x4y]], [[2x4x|2x4x]]</div></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4w OCA], [https://pdbe.org/2x4w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x4w RCSB], [https://www.ebi.ac.uk/pdbsum/2x4w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4w ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4w OCA], [https://pdbe.org/2x4w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x4w RCSB], [https://www.ebi.ac.uk/pdbsum/2x4w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4w ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN]] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref>
[https://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/2x4w_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/2x4w_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Allen, M D]]
[[Category: Allen MD]]
[[Category: Bonadies, N]]
[[Category: Bonadies N]]
[[Category: Bycroft, M]]
[[Category: Bycroft M]]
[[Category: Freund, S M.V]]
[[Category: Freund SMV]]
[[Category: Gottgens, B]]
[[Category: Gottgens B]]
[[Category: Huntly, B J.P]]
[[Category: Huntly BJP]]
[[Category: Kvinlaug, B]]
[[Category: Kvinlaug B]]
[[Category: Santiveri, C M]]
[[Category: Santiveri CM]]
[[Category: Vezzoli, A]]
[[Category: Vezzoli A]]
[[Category: Chromatin regulator]]
[[Category: Metal-binding]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Zinc-finger]]
Retrieved from "https://proteopedia.org/2x4w"