4b1q: Difference between revisions
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==NMR structure of the glycosylated conotoxin CcTx from Conus consors== | ==NMR structure of the glycosylated conotoxin CcTx from Conus consors== | ||
<StructureSection load='4b1q' size='340' side='right'caption='[[4b1q | <StructureSection load='4b1q' size='340' side='right'caption='[[4b1q]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4b1q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_consors Conus consors]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B1Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B1Q FirstGlance]. <br> | <table><tr><td colspan='2'>[[4b1q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_consors Conus consors]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B1Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B1Q FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand= | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GXL:ALPHA-L-GALACTOPYRANOSE'>GXL</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b1q OCA], [https://pdbe.org/4b1q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b1q RCSB], [https://www.ebi.ac.uk/pdbsum/4b1q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b1q ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b1q OCA], [https://pdbe.org/4b1q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b1q RCSB], [https://www.ebi.ac.uk/pdbsum/4b1q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b1q ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/CEX_CONCN CEX_CONCN] May specifically activate neuronal voltage-gated sodium channels (Nav) at the resting membrane potential. Causes a marked contraction and extension of the caudal and dorsal fins in fish and noticeable spontaneous contractions of isolated frog neuromuscular preparations. | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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[[Category: Conus consors]] | [[Category: Conus consors]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Boelens | [[Category: Boelens R]] | ||
[[Category: Favreau | [[Category: Favreau P]] | ||
[[Category: Gerwig | [[Category: Gerwig GJ]] | ||
[[Category: Hocking | [[Category: Hocking HG]] | ||
[[Category: Kamerling | [[Category: Kamerling JP]] | ||
[[Category: Stocklin | [[Category: Stocklin R]] | ||
Latest revision as of 08:34, 9 April 2025
NMR structure of the glycosylated conotoxin CcTx from Conus consors
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