Sandbox Reserved 1844: Difference between revisions
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=== Ligand Binding Pocket === | === Ligand Binding Pocket === | ||
The <scene name='10/1075246/4eb0_with_colored_ligand_stick/3'>substrate-binding site</scene> of LCC is a long, mainly <scene name='10/1075246/4eb0_hydrophobicity_ligand/ | The <scene name='10/1075246/4eb0_with_colored_ligand_stick/3'>substrate-binding site</scene> of LCC is a long, mainly <scene name='10/1075246/4eb0_hydrophobicity_ligand/3'>hydrophobic groove</scene> that accommodates PET chains. This groove includes three subsites—designated −2, −1, and +1—that interact with specific PET units near the scissile ester bond. Hydrophobic residues such as F125, V212, M166, and F243 line the groove and facilitate binding by interacting with the aromatic rings of the PET molecule. These interactions help align the substrate in the correct position for catalysis. | ||
[[Image:Final rayed image of binding pocket.png|400 px|right|thumb|Figure 2: Ser, His, Asp Catalytic Triad]] | [[Image:Final rayed image of binding pocket.png|400 px|right|thumb|Figure 2: Ser, His, Asp Catalytic Triad]] | ||
<scene name='10/1075246/4eb0_surface_w_stick_ligand/1'>Molecular surface view of enzyme-ligand interaction</scene> | <scene name='10/1075246/4eb0_surface_w_stick_ligand/1'>Molecular surface view of enzyme-ligand interaction</scene> | ||
