DNA damage-binding protein

spinqualitylabelsall models Human DDB1 (cyan) and DDB2 (green) complex with DNA, and tetraethylene glycol (PDB code 3ei1). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function DNA damage-binding protein (DDB) functions in nucleotide excision repair. It prevents UV damage to DNA. DDB is a heterodimer composed of the large DDB1 and the smaller DNA-binding DDB2. DNA in this complex with DDB1 and DDB2 contains modified compounds 5PY and 64T (in darkmagenta and magenta, respectively), they are derivatives from parent compound THYMIDINE-5'-MONOPHOSPHATE. Water molecules shown as red spheres. Disease Defective activity of DDB2 causes the repair defects in patients with XPE - an autosomal disorder characterized by early onset of cancer and photosensitivity. 3D Structures of DNA damage-binding protein DNA damage-binding protein 3D structures Updated on 16-April-2025 {"openlevels":0} DDB1 3e0c – hDDB - human 2b5m, 2b5n – hDDB BPB domain DDB1 binary complex 2b5l – hDDB + simian virus 5 protein 3i7h, 3i7k, 3i7l, 3i7n, 3i7o, 3i7p, 3i89, 3i8c, **3i8e – hDDB + X protein peptide 6dsz – hDDB + DET1 peptide 4a11, 6fcv – hDDB + DNA excision repair protein ERCC-8 8d7x, 8d7y – hDDB + cereblon 8cvp – hDDB + cereblon – Cryo EM 6zue – hDDB + DCAF1 8ajn – hDDB + DCAF1 – Cryo EM 7ukn – hDDB + herpes virus protein br /> 7p7b – hDDB + VPRBP – Cryo EM DDB1 ternary complex 4ci1, 4ci2, 4ci3, 4tz4, 8d81 – hDDB + cereblon + thalidomide derivative 5v3o – hDDB + cereblon + piperidine derivative 5fqd – hDDB + cereblon + casein kinase 1 5hxb, 6xk9 – hDDB + cereblon + ERF3A 6bn8, 6bn9, 6bnb, 6boy – hDDB + cereblon + BRD4 7lps – hDDB + cereblon + IKAROS 8d7u, 8d7v, 8d7w – hDDB + cereblon + mezigdomide 6h0f – hDDB (mutant) + cereblon + IKAROS 6h0g – hDDB (mutant) + cereblon + ZNF692 6td3 – hDDB + cyclin-dependent kinase 12 + cyclin-K 7zn7, 7znn – hDDB (mutant) + herpes virus protein + STAT2 – Cryo EM 6zx9 – hDDB + SIV protein + VPRBP 8ajm, 8ajo – hDDB + DCAF1 + CCT5 – Cryo EM DDB1 quaternary complex 6uml – hDDB + cereblon + ZNF797 + thalidomide derivative 6bn7 – hDDB + cereblon + BRD4 + piperidine derivative 8d7z, 8d80 – hDDB + cereblon + IKAROS + drug 2hye – hDDB + simian virus 5 protein + cullin-4A + ring-box protein 1 5jk7 – hDDB + HIV protein + uracil-DNA glycosylase + VPRBP 7v7c – hDDB + HIV protein + uracil-DNA glycosylase + VPRBP – Cryo EM 7okq – hDDB + DCAF1 + cullin-4A + RBX1 – Cryo EM 6pai, 6q0r, 6ue5 – hDDB + DDA1 + RNA-binding protein 39 + DET1 + sulfonamide derivative 6q0v, 6q0w, 6ud7 – hDDB + DDA1 + RNA-binding protein 39 + DET1 + anti-cancer drug 6sj7 – hDDB + DDA1 + RNA-binding protein 39 + DET1 + anti-cancer drug – Cryo EM 7oo3, 7oob, 7oop, 7opc, 7opd – hDDB in transcription-DNA repair coupling – Cryo EM DDB1+DDB2 3ei3, 3ei4 – hDDB 3ei1, 3ei2, 4a08, 4a09, 4a0a, 4a0b, 4e54, 4e5z – hDDB + DNA 4a0k – hDDB + cullin-4A + ring-box protein 1 4a0l – hDDB + cullin-4A + ring-box protein 1 + DNA 6r8y, 6r8z, 6r90, 6r91, 6r92 – hDDB + histones + DNA – Cryo EM

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