8z73: Difference between revisions
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==Crystal Structure of AF9 in complex with H3K9la peptide== | |||
<StructureSection load='8z73' size='340' side='right'caption='[[8z73]], [[Resolution|resolution]] 2.91Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8z73]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Z73 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Z73 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.906Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=XRW:N~6~-[(2S)-2-hydroxypropanoyl]-L-lysine'>XRW</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8z73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8z73 OCA], [https://pdbe.org/8z73 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8z73 RCSB], [https://www.ebi.ac.uk/pdbsum/8z73 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8z73 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/AF9_HUMAN AF9_HUMAN] A chromosomal aberration involving MLLT3 is associated with acute leukemias. Translocation t(9;11)(p22;q23) with KMT2A/MLL1. The result is a rogue activator protein. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/AF9_HUMAN AF9_HUMAN] Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.<ref>PMID:20159561</ref> <ref>PMID:20471948</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Li HT]] | |||
[[Category: Ma HD]] | |||
Latest revision as of 05:18, 23 April 2025
Crystal Structure of AF9 in complex with H3K9la peptide
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