User:Matthew Chien/Sandbox 1: Difference between revisions
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=== Innate Immunity === | === Innate Immunity === | ||
C1q plays a major role in the innate part of the immune system. It is the first complement protein to be activated in the classical complement pathway. This pathway of complement activation is dependent on the detection of antibody-antigen complexes, which creates a cascade of complement protein activation to ultimately promote inflammation, enhance the performance of various immune cells, and attack the pathogen's cell membrane. This acts as an irreplicable aspect of the innate immune system and is one of the body's primary defense against invaders. | C1q plays a major role in the '''innate''' part of the immune system. It is the first complement protein to be activated in the classical complement pathway. This pathway of complement activation is dependent on the detection of antibody-antigen complexes, which creates a cascade of complement protein activation to ultimately promote inflammation, enhance the performance of various immune cells, and attack the pathogen's cell membrane. This acts as an irreplicable aspect of the innate immune system and is one of the body's primary defense against invaders. | ||
C1q is also known to be a kind of opsonin, which is a protein that tags a foreign cell to be engulfed and destroyed by phagocytes, such as neutrophils and macrophages. This process is a very important aspect of the innate immune system to eliminate foreign bacteria and viruses to keep the host healthy. It has been shown that both neutrophils and macrophages posses receptors capable of binding the globular head and CLR of C1q, named gC1qR and cC1qR respectively, emphasizing their crucial role for phagocytes to identify and eliminate foreign pathogens. Immature dendritic cells have also been shown to contain a large amounts of gC1qR and cC1qR. This acts as an important bridge between the innate and adaptive immune systems; dendritic cells can survey certain areas based on the amount of present C1q in order to activate and begin digesting antigens to present to T-cells, which is a crucial step in adaptive immunity activation. <ref>PMID:9407113</ref><ref>PMID:28104818</ref> | C1q is also known to be a kind of opsonin, which is a protein that tags a foreign cell to be engulfed and destroyed by phagocytes, such as neutrophils and macrophages. This process is a very important aspect of the innate immune system to eliminate foreign bacteria and viruses to keep the host healthy. It has been shown that both neutrophils and macrophages posses receptors capable of binding the globular head and CLR of C1q, named gC1qR and cC1qR respectively, emphasizing their crucial role for phagocytes to identify and eliminate foreign pathogens. Immature dendritic cells have also been shown to contain a large amounts of gC1qR and cC1qR. This acts as an important bridge between the innate and adaptive immune systems; dendritic cells can survey certain areas based on the amount of present C1q in order to activate and begin digesting antigens to present to T-cells, which is a crucial step in adaptive immunity activation. <ref>PMID:9407113</ref><ref>PMID:28104818</ref> | ||
=== Adaptive Immunity === | === Adaptive Immunity === | ||
As iterated above, C1q is important in the activation phase of the adaptive immune response. In addition, C1q plays a major role in the solubilization of certain immune complexes, mainly the antibody-antigen complex. One of the main roles of C1q is to bind to these complexes at the Fc region of Immunoglobulin (Ig) G and IgM when bonded to an antigen. This activates the classical cascade of the complement system but also prevents the immune complex from becoming insoluble, which could lead to further unnecessary inflammation as they can no longer be detected by phagocytes for destruction. C1q, especially the globular head region, is known to be profoundly <scene name='10/1078778/Surface_Potential/1'>positively charged</scene> and is a key component in the prevention of preformed immune precipitation, along with other components of the classical complement pathway. | As iterated above, C1q is important in the activation phase of the '''adaptive''' immune response. In addition, C1q plays a major role in the solubilization of certain immune complexes, mainly the antibody-antigen complex. One of the main roles of C1q is to bind to these complexes at the Fc region of Immunoglobulin (Ig) G and IgM when bonded to an antigen. This activates the classical cascade of the complement system but also prevents the immune complex from becoming insoluble, which could lead to further unnecessary inflammation as they can no longer be detected by phagocytes for destruction. C1q, especially the globular head region, is known to be profoundly <scene name='10/1078778/Surface_Potential/1'>positively charged</scene> and is a key component in the prevention of preformed immune precipitation, along with other components of the classical complement pathway. | ||
C1q has been shown to partially facilitate the function of T-cells. The receptors gC1qR and cC1qR are both present on T-cells and serve as both activators and inhibitors. In the presence of immune complexes, C1q has shown to activate T-cells, acting as a bridge between the innate and adaptive immune system. In terms of inhibition, C1q is observed to suppress the activity of T-cells in certain environments to regulate the immune system and prevent autoimmune disease. C1q is known to bind to various phospholipids, namely phosphatidylserine, which is largely present on the surface of apoptotic cells. This promotes opsonization by complement proteins such as C1q which leads to macrophage activation while also inhibiting T-cells to interact with the apoptotic cells. Over-activation of T-cells can lead to unnecessary harm within the body when their presence is not necessary and phagocytes are favored. <ref>PMID:15982298</ref><ref>PMID:20010915</ref> | C1q has been shown to partially facilitate the function of T-cells. The receptors gC1qR and cC1qR are both present on T-cells and serve as both activators and inhibitors. In the presence of immune complexes, C1q has shown to activate T-cells, acting as a bridge between the innate and adaptive immune system. In terms of inhibition, C1q is observed to suppress the activity of T-cells in certain environments to regulate the immune system and prevent autoimmune disease. C1q is known to bind to various phospholipids, namely phosphatidylserine, which is largely present on the surface of apoptotic cells. This promotes opsonization by complement proteins such as C1q which leads to macrophage activation while also inhibiting T-cells to interact with the apoptotic cells. Over-activation of T-cells can lead to unnecessary harm within the body when their presence is not necessary and phagocytes are favored. <ref>PMID:15982298</ref><ref>PMID:20010915</ref> | ||
