9dgi: Difference between revisions

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'''Unreleased structure'''


The entry 9dgi is ON HOLD  until Paper Publication
==Cannabinoid receptor 1-Gi complex with novel ligand==
 
<StructureSection load='9dgi' size='340' side='right'caption='[[9dgi]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
Authors: Tummino, T.A., Iliopoulos-Tsoutsouvas, C., Braz, J.M., O''Brien, E.S., Krishna Kumar, K., Makriyannis, M., Basbaum, A.I., Shoichet, B.K.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9dgi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DGI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DGI FirstGlance]. <br>
Description: Cannabinoid receptor 1-Gi complex with novel ligand
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.35&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YVF:methyl+(2R)-2-({(1M)-5-methyl-1-[3-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonyl}amino)-2-(thiophen-2-yl)propanoate'>YVF</scene></td></tr>
[[Category: Iliopoulos-Tsoutsouvas, C]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9dgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9dgi OCA], [https://pdbe.org/9dgi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9dgi RCSB], [https://www.ebi.ac.uk/pdbsum/9dgi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9dgi ProSAT]</span></td></tr>
[[Category: Tummino, T.A]]
</table>
[[Category: Makriyannis, M]]
== Function ==
[[Category: O''Brien, E.S]]
[https://www.uniprot.org/uniprot/CNR1_HUMAN CNR1_HUMAN] Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.<ref>PMID:15620723</ref>
[[Category: Shoichet, B.K]]
== References ==
[[Category: Krishna Kumar, K]]
<references/>
[[Category: Braz, J.M]]
__TOC__
[[Category: Basbaum, A.I]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Basbaum AI]]
[[Category: Braz JM]]
[[Category: Iliopoulos-Tsoutsouvas C]]
[[Category: Krishna Kumar K]]
[[Category: Makriyannis M]]
[[Category: O'Brien ES]]
[[Category: Shoichet BK]]
[[Category: Tummino TA]]
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