User:Adam Davis/Sandbox 1: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Adam Davis (talk | contribs) No edit summary |
Adam Davis (talk | contribs) No edit summary |
||
| Line 2: | Line 2: | ||
== Introduction == | == Introduction == | ||
Peroxisome proliferator activated receptors ([[PPAR]]s) are ligand-activated transcription factors that regulate metabolism. They are divided into three families: α, γ, and δ. PPARδ is activated by endogenous lipids, and plays a role in the regulation of lipid metabolism. Synthetic PPARδ agonists hold significant promise for treatment of metabolic and cardiovascular diseases. (Note: In the literature, PPARδ is sometimes also called PPARβ). In this structure, PPARδ is bound to a synthetic agonist, GW074, which binds PPARδ 300-fold more tightly than PPARα and PPARγ. | Peroxisome proliferator activated receptors ([[PPAR]]s) are ligand-activated transcription factors that regulate metabolism. They are divided into three families: α, γ, and δ. PPARδ is activated by endogenous lipids, and plays a role in the regulation of lipid metabolism. Synthetic PPARδ agonists hold significant promise for treatment of metabolic and cardiovascular diseases. (Note: In the literature, PPARδ is sometimes also called PPARβ). In this structure, PPARδ is bound to a synthetic agonist, GW074, which binds PPARδ 300-fold more tightly than PPARα and PPARγ<ref>DOI 10.1371/journal.pone.0033643</ref>. | ||
<StructureSection load='3tkm' size='340' side='right' caption='PDB ID: 3TKM' scene=''> | <StructureSection load='3tkm' size='340' side='right' caption='PDB ID: 3TKM' scene=''> | ||
