9now: Difference between revisions
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==Human sweet taste receptor (TAS1R2 + TAS1R3) VFT domains bound to aspartame== | |||
<StructureSection load='9now' size='340' side='right'caption='[[9now]], [[Resolution|resolution]] 3.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9now]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NOW FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9now FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9now OCA], [https://pdbe.org/9now PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9now RCSB], [https://www.ebi.ac.uk/pdbsum/9now PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9now ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TS1R3_HUMAN TS1R3_HUMAN] Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.<ref>PMID:11917125</ref> <ref>PMID:12892531</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Chang AN]] | |||
[[Category: Fitzpatrick AWP]] | |||
[[Category: Juen Z]] | |||
[[Category: Lu Z]] | |||
[[Category: Wang B]] | |||
[[Category: Yu R]] | |||
[[Category: Zuker CS]] | |||
Latest revision as of 05:48, 14 May 2025
Human sweet taste receptor (TAS1R2 + TAS1R3) VFT domains bound to aspartame
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