9qyg: Difference between revisions
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==PARP9 Macro Domain 2 Free form== | |||
<StructureSection load='9qyg' size='340' side='right'caption='[[9qyg]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9qyg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9QYG FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9qyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9qyg OCA], [https://pdbe.org/9qyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9qyg RCSB], [https://www.ebi.ac.uk/pdbsum/9qyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9qyg ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Disease == | ||
[[Category: | [https://www.uniprot.org/uniprot/PARP9_HUMAN PARP9_HUMAN] Overexpressed at significantly higher levels in fatal high-risk diffuse large B-cell lymphomas (DLB-CL) compared to cured low-risk tumors. Overexpression in B-cell lymphoma transfectants may promote malignant B-cell migration. May therefore be involved in promoting B-cell migration and dissemination of high-risk DLB-CL tumors. | ||
[[Category: Spyroulias | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/PARP9_HUMAN PARP9_HUMAN] In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes.<ref>PMID:16809771</ref> <ref>PMID:23230272</ref> | ||
[[Category: | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Chikunova A]] | |||
[[Category: Fourkiotis KN]] | |||
[[Category: Kravvariti PK]] | |||
[[Category: Perrakis A]] | |||
[[Category: Spyroulias AG]] | |||
[[Category: Tsatsouli AS]] | |||
[[Category: Tsika CA]] | |||
