6xow: Difference between revisions

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<StructureSection load='6xow' size='340' side='right'caption='[[6xow]], [[Resolution|resolution]] 4.60&Aring;' scene=''>
<StructureSection load='6xow' size='340' side='right'caption='[[6xow]], [[Resolution|resolution]] 4.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6xow]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XOW FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XOW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.6&#8491;</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xow OCA], [https://pdbe.org/6xow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xow RCSB], [https://www.ebi.ac.uk/pdbsum/6xow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xow ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xow OCA], [https://pdbe.org/6xow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xow RCSB], [https://www.ebi.ac.uk/pdbsum/6xow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xow ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PREP_HUMAN PREP_HUMAN] ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.<ref>PMID:16849325</ref>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Liang WG]]
[[Category: Liang WG]]
[[Category: Tang W]]
[[Category: Tang W]]

Latest revision as of 08:49, 4 June 2025

CryoEM structure of human presequence protease in partial close state 2, induced by presequence of citrate synthase

6xow, resolution 4.60Å

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