8y2o: Difference between revisions

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'''Unreleased structure'''


The entry 8y2o is ON HOLD  until 2026-07-26
==The Cryo-EM structure of human tRNA methyltransferase FTSJ1-THADA with substrate tRNA and S-adenosyl homocysteine (SAH)==
 
<StructureSection load='8y2o' size='340' side='right'caption='[[8y2o]], [[Resolution|resolution]] 2.66&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8y2o]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Y2O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Y2O FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.66&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8y2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8y2o OCA], [https://pdbe.org/8y2o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8y2o RCSB], [https://www.ebi.ac.uk/pdbsum/8y2o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8y2o ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/THADA_HUMAN THADA_HUMAN] Chromosomal aberrations involving THADA have been observed in benign thyroid adenomas. Translocation t(2;3)(p21;p25) and translocation t(2;7)(p21;p15); the sequences derived from chromosomes 3p25 and 7p15 do not appear to include a coding region and the fusion events probably result in truncated THADA proteins.
== Function ==
[https://www.uniprot.org/uniprot/THADA_HUMAN THADA_HUMAN] Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs.<ref>PMID:25404562</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Fujimura A]]
[[Category: Ishiguro K]]
[[Category: Shirouzu M]]
Retrieved from "https://proteopedia.org/8y2o"