9caa: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

The entry ~~9caa is ON HOLD until Paper Publication~~

==Cryo-EM structure of human SRCAP-nucleosome complex in the pre-engaged state (composite structure)==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9caa]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9CAA OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9CAA FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.04Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9caa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9caa OCA], [https://pdbe.org/9caa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9caa RCSB], [https://www.ebi.ac.uk/pdbsum/9caa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9caa ProSAT]</td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/SRCAP_HUMAN SRCAP_HUMAN] Floating-Harbor syndrome. The disease is caused by mutations affecting the gene represented in this entry.

== Function ==

[https://www.uniprot.org/uniprot/SRCAP_HUMAN SRCAP_HUMAN] Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.<ref>PMID:10347196</ref> <ref>PMID:11522779</ref> <ref>PMID:14500758</ref> <ref>PMID:16024792</ref> <ref>PMID:16634648</ref> <ref>PMID:17617668</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Xenopus laevis]]

[[Category: Louder RK]]

[[Category: Park G]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9caa is ON HOLD  until Paper Publication
+==Cryo-EM structure of human SRCAP-nucleosome complex in the pre-engaged state (composite structure)==
+<StructureSection load='9caa' size='340' side='right'caption='[[9caa]], [[Resolution|resolution]] 4.04&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9caa]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9CAA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9CAA FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.04&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9caa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9caa OCA], [https://pdbe.org/9caa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9caa RCSB], [https://www.ebi.ac.uk/pdbsum/9caa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9caa ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/SRCAP_HUMAN SRCAP_HUMAN] Floating-Harbor syndrome. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/SRCAP_HUMAN SRCAP_HUMAN] Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.<ref>PMID:10347196</ref> <ref>PMID:11522779</ref> <ref>PMID:14500758</ref> <ref>PMID:16024792</ref> <ref>PMID:16634648</ref> <ref>PMID:17617668</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Xenopus laevis]]
+[[Category: Louder RK]]
+[[Category: Park G]]