9el5: Difference between revisions
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==FANCM translocase domain bound to DNA== | |||
<StructureSection load='9el5' size='340' side='right'caption='[[9el5]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9el5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EL5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EL5 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9el5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9el5 OCA], [https://pdbe.org/9el5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9el5 RCSB], [https://www.ebi.ac.uk/pdbsum/9el5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9el5 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Bythell-Douglas | == Disease == | ||
[[Category: Chapman | [https://www.uniprot.org/uniprot/FANCM_HUMAN FANCM_HUMAN] Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry. | ||
[[Category: | == Function == | ||
[[Category: Murphy | [https://www.uniprot.org/uniprot/FANCM_HUMAN FANCM_HUMAN] ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions.<ref>PMID:16116422</ref> <ref>PMID:16116434</ref> [REFERENCE:7][REFERENCE:8] | ||
[[Category: | == References == | ||
[[Category: Wolf | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Abbouche L]] | |||
[[Category: Bythell-Douglas R]] | |||
[[Category: Chapman K]] | |||
[[Category: Deans AJ]] | |||
[[Category: Murphy V]] | |||
[[Category: Rigoreau L]] | |||
[[Category: Wolf J]] | |||
Latest revision as of 10:59, 18 June 2025
FANCM translocase domain bound to DNA
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