9jn9: Difference between revisions
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The entry | ==Cryo-EM structure of human SLFN14== | ||
<StructureSection load='9jn9' size='340' side='right'caption='[[9jn9]], [[Resolution|resolution]] 3.36Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9jn9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JN9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JN9 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.36Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jn9 OCA], [https://pdbe.org/9jn9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jn9 RCSB], [https://www.ebi.ac.uk/pdbsum/9jn9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jn9 ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/SLN14_HUMAN SLN14_HUMAN] Autosomal dominant thrombocytopenia with platelet secretion defect. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SLN14_HUMAN SLN14_HUMAN] Shows no ribosome-associated and endoribonuclease activities.<ref>PMID:25996083</ref> Displays polysome-associated endoribonuclease activity towards mRNAs and rRNAs (PubMed:25996083). May play a role in RNA surveillance pathways by recognizing stalled ribosomes and triggering endonucleolytic cleavage of aberrant mRNAs (Probable). Cleaves different types of rRNAs and mRNAs in a magnesium- and manganese-dependent and ATP-independent manner (By similarity). Involved in correct maturation of megakaryocytes and especially important for proplatelet extension.[UniProtKB:G1SRW8]<ref>PMID:25996083</ref> <ref>PMID:26769223</ref> <ref>PMID:25996083</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Gao S]] | |||
[[Category: Jia XD]] | |||
[[Category: Luo M]] | |||
[[Category: Wang ZW]] | |||
[[Category: Yang JY]] | |||
[[Category: Zhang QF]] | |||
Latest revision as of 11:07, 18 June 2025
Cryo-EM structure of human SLFN14
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