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| Line 8: |
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| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j4u OCA], [https://pdbe.org/8j4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j4u RCSB], [https://www.ebi.ac.uk/pdbsum/8j4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j4u ProSAT]</span></td></tr> | | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j4u OCA], [https://pdbe.org/8j4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j4u RCSB], [https://www.ebi.ac.uk/pdbsum/8j4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j4u ProSAT]</span></td></tr> |
| </table> | | </table> |
| == Function ==
| |
| [https://www.uniprot.org/uniprot/A0A7B5N0T7_ECOLX A0A7B5N0T7_ECOLX]
| |
| <div style="background-color:#fffaf0;">
| |
| == Publication Abstract from PubMed ==
| |
| In response to the persistent exposure to phage infection, bacteria have evolved diverse antiviral defense mechanisms. In this study, we report a bacterial two-component defense system consisting of a Sir2 NADase and a HerA helicase. Cryo-electron microscopy reveals that Sir2 and HerA assemble into a approximately 1 MDa supramolecular octadecamer. Unexpectedly, this complex exhibits various enzymatic activities, including ATPase, NADase, helicase, and nuclease, which work together in a sophisticated manner to fulfill the antiphage function. Therefore, we name this defense system "Nezha" after a divine warrior in Chinese mythology who employs multiple weapons to defeat enemies. Our findings demonstrate that Nezha could sense phage infections, self-activate to arrest cell growth, eliminate phage genomes, and subsequently deactivate to allow for cell recovery. Collectively, Nezha represents a paradigm of sophisticated and multifaceted strategies bacteria use to defend against viral infections.
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|
| |
| Multiple enzymatic activities of a Sir2-HerA system cooperate for anti-phage defense.,Tang D, Chen Y, Chen H, Jia T, Chen Q, Yu Y Mol Cell. 2023 Dec 21;83(24):4600-4613.e6. doi: 10.1016/j.molcel.2023.11.010. , Epub 2023 Dec 13. PMID:38096825<ref>PMID:38096825</ref>
| |
|
| |
| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
| |
| </div>
| |
| <div class="pdbe-citations 8j4u" style="background-color:#fffaf0;"></div>
| |
| == References ==
| |
| <references/>
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| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |
