8j9w: Difference between revisions
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== | ==Cryo-EM structure of the African swine fever virus topoisomerase 2 complexed with Cut02bDNA and etoposide (EDI-2)== | ||
<StructureSection load='8j9w' size='340' side='right'caption='[[8j9w]]' scene=''> | <StructureSection load='8j9w' size='340' side='right'caption='[[8j9w]], [[Resolution|resolution]] 2.76Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J9W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J9W FirstGlance]. <br> | <table><tr><td colspan='2'>[[8j9w]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/African_swine_fever_virus African swine fever virus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J9W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J9W FirstGlance]. <br> | ||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.76Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EVP:(5S,5AR,8AR,9R)-9-(4-HYDROXY-3,5-DIMETHOXYPHENYL)-8-OXO-5,5A,6,8,8A,9-HEXAHYDROFURO[3,4 6,7]NAPHTHO[2,3-D][1,3]DIOXOL-5-YL+4,6-O-[(1R)-ETHYLIDENE]-BETA-D-GLUCOPYRANOSIDE'>EVP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j9w OCA], [https://pdbe.org/8j9w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j9w RCSB], [https://www.ebi.ac.uk/pdbsum/8j9w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j9w ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j9w OCA], [https://pdbe.org/8j9w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j9w RCSB], [https://www.ebi.ac.uk/pdbsum/8j9w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j9w ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/TOP2_ASFB7 TOP2_ASFB7] Type II topoisomerase (PubMed:25463606, PubMed:27060564). Processively relaxes supercoiled DNA (PubMed:27060564). Displays DNA-supercoiling activity only when associated with the viral histone-like protein (PubMed:28381576).<ref>PMID:25463606</ref> <ref>PMID:27060564</ref> <ref>PMID:28381576</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: African swine fever virus]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Chang C-W]] | ||
[[Category: Tsai M-D]] | |||
Latest revision as of 06:53, 25 June 2025
Cryo-EM structure of the African swine fever virus topoisomerase 2 complexed with Cut02bDNA and etoposide (EDI-2)
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