9n1f: Difference between revisions
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==Crystal Structure of the Ark2C-Ubc13~Ub-Mms2 complex== | |||
<StructureSection load='9n1f' size='340' side='right'caption='[[9n1f]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9n1f]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9N1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9N1F FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9n1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9n1f OCA], [https://pdbe.org/9n1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9n1f RCSB], [https://www.ebi.ac.uk/pdbsum/9n1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9n1f ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ARK2C_HUMAN ARK2C_HUMAN] E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL.[UniProtKB:E9QAU8] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Day CL]] | |||
[[Category: Middleton AJ]] | |||
[[Category: Paluda A]] | |||
Latest revision as of 07:26, 25 June 2025
Crystal Structure of the Ark2C-Ubc13~Ub-Mms2 complex
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