9cdt: Difference between revisions
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==Crystal Structure of MCL-1-Peptide Complex== | |||
<StructureSection load='9cdt' size='340' side='right'caption='[[9cdt]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9cdt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9CDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9CDT FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9cdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9cdt OCA], [https://pdbe.org/9cdt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9cdt RCSB], [https://www.ebi.ac.uk/pdbsum/9cdt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9cdt ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Bera AK]] | |||
[[Category: Bhardwaj G]] | |||
[[Category: Kang A]] | |||
[[Category: Rettie S]] | |||
Latest revision as of 05:22, 3 July 2025
Crystal Structure of MCL-1-Peptide Complex
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