9jl0: Difference between revisions
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==Crystal structure of feline CD8aa homodimer== | |||
<StructureSection load='9jl0' size='340' side='right'caption='[[9jl0]], [[Resolution|resolution]] 2.48Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9jl0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Felis_catus Felis catus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JL0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JL0 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.48Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jl0 OCA], [https://pdbe.org/9jl0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jl0 RCSB], [https://www.ebi.ac.uk/pdbsum/9jl0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jl0 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Li | == Function == | ||
[https://www.uniprot.org/uniprot/CD8A_FELCA CD8A_FELCA] Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.[UniProtKB:P01732] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Felis catus]] | |||
[[Category: Large Structures]] | |||
[[Category: Li Z]] | |||
[[Category: Liang R]] | |||
Latest revision as of 05:32, 3 July 2025
Crystal structure of feline CD8aa homodimer
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