9m36: Difference between revisions
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==Structure of human TRPC5 in the low Ca environment.== | |||
<StructureSection load='9m36' size='340' side='right'caption='[[9m36]], [[Resolution|resolution]] 2.48Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9m36]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9M36 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9M36 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.48Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1L5I:[(2~{S})-2-[(~{E})-octadec-9-enoyl]oxy-3-oxidanyl-propyl]+octadec-9-enoate'>A1L5I</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9m36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9m36 OCA], [https://pdbe.org/9m36 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9m36 RCSB], [https://www.ebi.ac.uk/pdbsum/9m36 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9m36 ProSAT]</span></td></tr> | ||
[[Category: Chen | </table> | ||
[[Category: Wei | == Function == | ||
[https://www.uniprot.org/uniprot/TRPC5_HUMAN TRPC5_HUMAN] Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity).[UniProtKB:Q9QX29]<ref>PMID:16284075</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Chen L]] | |||
[[Category: Song KC]] | |||
[[Category: Wei M]] | |||
Latest revision as of 05:34, 3 July 2025
Structure of human TRPC5 in the low Ca environment.
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