9m4t: Difference between revisions
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==CryoEM structure of the alpha1AAR complex with silodosin== | |||
<StructureSection load='9m4t' size='340' side='right'caption='[[9m4t]], [[Resolution|resolution]] 3.19Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9m4t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9M4T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9M4T FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.19Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EMV:1-(3-oxidanylpropyl)-5-[(2~{R})-2-[2-[2-[2,2,2-tris(fluoranyl)ethoxy]phenoxy]ethylamino]propyl]-2,3-dihydroindole-7-carboxamide'>A1EMV</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9m4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9m4t OCA], [https://pdbe.org/9m4t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9m4t RCSB], [https://www.ebi.ac.uk/pdbsum/9m4t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9m4t ProSAT]</span></td></tr> | ||
[[Category: Guo | </table> | ||
[[Category: Tao | == Function == | ||
[https://www.uniprot.org/uniprot/ADA1A_HUMAN ADA1A_HUMAN] This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.<ref>PMID:18802028</ref> <ref>PMID:22120526</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Guo Q]] | |||
[[Category: Jiao HZ]] | |||
[[Category: Liu SS]] | |||
[[Category: Tao YY]] | |||
[[Category: Wang DD]] | |||
Latest revision as of 05:34, 3 July 2025
CryoEM structure of the alpha1AAR complex with silodosin
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