9m5v: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9m5v is ~~ON HOLD until Paper Publication~~

==Structure of human TRPC5 bound with (-)-englerin A,class1==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9m5v]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9M5V OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9M5V FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.53Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1L55:[(1~{S},2~{R},5~{R},6~{R},7~{S},8~{R},10~{R})-1,5-dimethyl-10-(2-oxidanylethanoyloxy)-8-propan-2-yl-11-oxatricyclo[6.2.1.0^{2,6}]undecan-7-yl]+(~{E})-3-phenylprop-2-enoate'>A1L55</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9m5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9m5v OCA], [https://pdbe.org/9m5v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9m5v RCSB], [https://www.ebi.ac.uk/pdbsum/9m5v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9m5v ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/TRPC5_HUMAN TRPC5_HUMAN] Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity).[UniProtKB:Q9QX29]<ref>PMID:16284075</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Chen L]]

[[Category: Chen YK]]

[[Category: Guo WJ]]

[[Category: Wei M]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9m5v is ON HOLD  until Paper Publication
+==Structure of human TRPC5 bound with (-)-englerin A,class1==
+<StructureSection load='9m5v' size='340' side='right'caption='[[9m5v]], [[Resolution|resolution]] 2.53&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9m5v]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9M5V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9M5V FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.53&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1L55:[(1~{S},2~{R},5~{R},6~{R},7~{S},8~{R},10~{R})-1,5-dimethyl-10-(2-oxidanylethanoyloxy)-8-propan-2-yl-11-oxatricyclo[6.2.1.0^{2,6}]undecan-7-yl]+(~{E})-3-phenylprop-2-enoate'>A1L55</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9m5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9m5v OCA], [https://pdbe.org/9m5v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9m5v RCSB], [https://www.ebi.ac.uk/pdbsum/9m5v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9m5v ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TRPC5_HUMAN TRPC5_HUMAN] Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity).[UniProtKB:Q9QX29]<ref>PMID:16284075</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Chen L]]
+[[Category: Chen YK]]
+[[Category: Guo WJ]]
+[[Category: Wei M]]