8iam: Difference between revisions

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<table><tr><td colspan='2'>[[8iam]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana], [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IAM FirstGlance]. <br>
<table><tr><td colspan='2'>[[8iam]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana], [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IAM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=Z1T:N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]tetracosanamide'>Z1T</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=Z1T:N-[(2S,3R)-1,3-bis(oxidanyl)octadec-4-en-2-yl]tetracosanamide'>Z1T</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8iam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8iam OCA], [https://pdbe.org/8iam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8iam RCSB], [https://www.ebi.ac.uk/pdbsum/8iam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8iam ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8iam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8iam OCA], [https://pdbe.org/8iam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8iam RCSB], [https://www.ebi.ac.uk/pdbsum/8iam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8iam ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LCB1_YEAST LCB1_YEAST] Component of serine palmitoyltransferase (SPT), which catalyzes the committed step in the synthesis of sphingolipids, the condensation of serine with palmitoyl CoA to form the long chain base 3-ketosphinganine.<ref>PMID:11781309</ref> <ref>PMID:8058731</ref> [https://www.uniprot.org/uniprot/LCB1_ARATH LCB1_ARATH] Serine palmitoyltransferase (SPT). The heterodimer formed with LCB2 constitutes the catalytic core. Involved in the regulation of the programmed cell death (PCD) signaling pathway. Plays an important role during male gametogenesis and embryogenesis.<ref>PMID:17194770</ref> <ref>PMID:18059378</ref> <ref>PMID:18218968</ref>
== References ==
<references/>
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</StructureSection>
</StructureSection>

Latest revision as of 06:50, 3 July 2025

Cryo-EM structure of the yeast SPT-ORM2 (ORM2-S3D) complex

8iam, resolution 3.10Å

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