9im4: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9im4 is ~~ON HOLD until Paper Publication~~

==Crystal Structure of AF9 YEATS domain F28R mutant in complex with histone H3K9la==

~~Authors~~: Li, H.T., Ma, H.D.

== Structural highlights ==

<table><tr><td colspan='2'>[[9im4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9IM4 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9IM4 FirstGlance].

~~Description~~: ~~Crystal Structure~~ of ~~AF9 YEATS domain F28R mutant in~~ complex ~~with histone H3K9la~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.794Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XRW:(2~{S})-2-azanyl-6-[[(2~{S})-2-oxidanylpropanoyl]amino]hexanoic+acid'>XRW</scene></td></tr>

[[Category: ~~Ma, H.D~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9im4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9im4 OCA], [https://pdbe.org/9im4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9im4 RCSB], [https://www.ebi.ac.uk/pdbsum/9im4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9im4 ProSAT]</td></tr>

[[Category: ~~Li, H.T~~]]

</table>

== Disease ==

[https://www.uniprot.org/uniprot/AF9_HUMAN AF9_HUMAN] A chromosomal aberration involving MLLT3 is associated with acute leukemias. Translocation t(9;11)(p22;q23) with KMT2A/MLL1. The result is a rogue activator protein.

== Function ==

[https://www.uniprot.org/uniprot/AF9_HUMAN AF9_HUMAN] Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.<ref>PMID:20159561</ref> <ref>PMID:20471948</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Li HT]]

[[Category: Ma HD]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9im4 is ON HOLD  until Paper Publication
+==Crystal Structure of AF9 YEATS domain F28R mutant in complex with histone H3K9la==
+<StructureSection load='9im4' size='340' side='right'caption='[[9im4]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
-Authors: Li, H.T., Ma, H.D.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9im4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9IM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9IM4 FirstGlance]. <br>
-Description: Crystal Structure of AF9 YEATS domain F28R mutant in complex with histone H3K9la
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.794&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XRW:(2~{S})-2-azanyl-6-[[(2~{S})-2-oxidanylpropanoyl]amino]hexanoic+acid'>XRW</scene></td></tr>
-[[Category: Ma, H.D]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9im4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9im4 OCA], [https://pdbe.org/9im4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9im4 RCSB], [https://www.ebi.ac.uk/pdbsum/9im4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9im4 ProSAT]</span></td></tr>
-[[Category: Li, H.T]]
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/AF9_HUMAN AF9_HUMAN] A chromosomal aberration involving MLLT3 is associated with acute leukemias. Translocation t(9;11)(p22;q23) with KMT2A/MLL1. The result is a rogue activator protein.
+== Function ==
+[https://www.uniprot.org/uniprot/AF9_HUMAN AF9_HUMAN] Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.<ref>PMID:20159561</ref> <ref>PMID:20471948</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Li HT]]
+[[Category: Ma HD]]