9oim: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

The ~~entry~~ 9oim is ~~ON HOLD~~

==The von Hippel Lindau-ElonginB-ElonginC (VCB) complex with fragment 9==

~~Authors~~: ~~Amporndanai~~, K., ~~Katinas, J~~.M., ~~Chopra~~, A., ~~Fesik~~, S.W.

== Structural highlights ==

<table><tr><td colspan='2'>[[9oim]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9OIM OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9OIM FirstGlance].

~~Description~~: The von Hippel Lindau~~-ElonginB-ElonginC~~ (~~VCB~~) ~~complex with fragment 9~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.61Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1CBI:1-(5-nitro-2,3-dihydro-1H-indol-1-yl)ethan-1-one'>A1CBI</scene>, <scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>

[[Category: ~~Chopra, A~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9oim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9oim OCA], [https://pdbe.org/9oim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9oim RCSB], [https://www.ebi.ac.uk/pdbsum/9oim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9oim ProSAT]</td></tr>

[[Category: ~~Katinas, J.M~~]]

</table>

[[Category: Fesik~~, S.W~~]]

== Function ==

[[Category: ~~Amporndanai, K~~]]

[https://www.uniprot.org/uniprot/ELOB_HUMAN ELOB_HUMAN] SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).<ref>PMID:7638163</ref> <ref>PMID:15590694</ref> The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.<ref>PMID:7638163</ref> <ref>PMID:15590694</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Amporndanai K]]

[[Category: Chopra A]]

[[Category: Fesik SW]]

[[Category: Katinas JM]]

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-'''Unreleased structure'''
-The entry 9oim is ON HOLD
+==The von Hippel Lindau-ElonginB-ElonginC (VCB) complex with fragment 9==
+<StructureSection load='9oim' size='340' side='right'caption='[[9oim]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
-Authors: Amporndanai, K., Katinas, J.M., Chopra, A., Fesik, S.W.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9oim]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9OIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9OIM FirstGlance]. <br>
-Description: The von Hippel Lindau-ElonginB-ElonginC (VCB) complex with fragment 9
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.61&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1CBI:1-(5-nitro-2,3-dihydro-1H-indol-1-yl)ethan-1-one'>A1CBI</scene>, <scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>
-[[Category: Chopra, A]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9oim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9oim OCA], [https://pdbe.org/9oim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9oim RCSB], [https://www.ebi.ac.uk/pdbsum/9oim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9oim ProSAT]</span></td></tr>
-[[Category: Katinas, J.M]]
+</table>
-[[Category: Fesik, S.W]]
+== Function ==
-[[Category: Amporndanai, K]]
+[https://www.uniprot.org/uniprot/ELOB_HUMAN ELOB_HUMAN] SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).<ref>PMID:7638163</ref> <ref>PMID:15590694</ref>   The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.<ref>PMID:7638163</ref> <ref>PMID:15590694</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Amporndanai K]]
+[[Category: Chopra A]]
+[[Category: Fesik SW]]
+[[Category: Katinas JM]]