9rp9: Difference between revisions
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==Crystal structure of mouse pVHL-ElonginB-ElonginC complex== | |||
<StructureSection load='9rp9' size='340' side='right'caption='[[9rp9]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9rp9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9RP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9RP9 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | ||
[[Category: Biterova | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9rp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9rp9 OCA], [https://pdbe.org/9rp9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9rp9 RCSB], [https://www.ebi.ac.uk/pdbsum/9rp9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9rp9 ProSAT]</span></td></tr> | ||
[[Category: Blat | </table> | ||
[[Category: Cukier | == Function == | ||
[https://www.uniprot.org/uniprot/Q3TTE7_MOUSE Q3TTE7_MOUSE] Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR.[ARBA:ARBA00059036] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Biterova E]] | |||
[[Category: Blat A]] | |||
[[Category: Cukier C]] | |||
Latest revision as of 16:30, 9 July 2025
Crystal structure of mouse pVHL-ElonginB-ElonginC complex
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