9knl: Difference between revisions

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'''Unreleased structure'''


The entry 9knl is ON HOLD  until 2026-11-19
==Crystal structure of triethylene glycol-bound full-length PHA synthase (PhaC) from Aeromonas caviae==
<StructureSection load='9knl' size='340' side='right'caption='[[9knl]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[9knl]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Aeromonas_caviae Aeromonas caviae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KNL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KNL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9knl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9knl OCA], [https://pdbe.org/9knl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9knl RCSB], [https://www.ebi.ac.uk/pdbsum/9knl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9knl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/O32471_AERCA O32471_AERCA]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Polyhydroxyalkanoate (PHA) is a biodegradable polyester that can serve as a promising alternative to petrochemical plastics, which present a serious source of pollution. PHA synthase (PhaC) is a key enzyme responsible for producing a wide variety of PHAs in microorganisms. Here, we present crystal structures of full-length PhaC from Aeromonas caviae, a high-performance PhaC employed for industrial use. The structure reveals an N-terminal helical domain that mediates head-to-head dimerization and stabilizes the C-terminal alpha/beta catalytic domain to form a tunnel that connects the catalytic center embedded inside the protein to the protein surface. We showed that this tunnel is a putative egress tunnel for the product PHA chain. Our results establish a fundamental understanding of the PhaC machinery that should lead to improvement of this enzyme in industrial applications.


Authors:  
Structures of Polyhydroxyalkanoate Synthase PhaC from Aeromonas caviae, Producing Biodegradable Plastics.,Chek MF, Kim SY, Mori T, Matsumoto K, Sato S, Hakoshima T Angew Chem Int Ed Engl. 2025 Apr 25:e202504626. doi: 10.1002/anie.202504626. PMID:40276819<ref>PMID:40276819</ref>


Description:  
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
<div class="pdbe-citations 9knl" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Aeromonas caviae]]
[[Category: Large Structures]]
[[Category: Chek MF]]
[[Category: Hakoshima T]]
[[Category: Kim SY]]
[[Category: Mori T]]
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