9qi5: Difference between revisions
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==Crystal structure of I105R mutant of BlaC from Mycobacterium tuberculosis== | |||
<StructureSection load='9qi5' size='340' side='right'caption='[[9qi5]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9qi5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QI5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9QI5 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[Category: Chikunova | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9qi5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9qi5 OCA], [https://pdbe.org/9qi5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9qi5 RCSB], [https://www.ebi.ac.uk/pdbsum/9qi5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9qi5 ProSAT]</span></td></tr> | ||
[[Category: Radojkovic | </table> | ||
[[Category: Ubbink | == Function == | ||
[https://www.uniprot.org/uniprot/BLAC_MYCBO BLAC_MYCBO] Extended spectrum beta-lactamase (ESBL) that inactivates beta-lactam antibiotics by hydrolyzing the amide group of the beta-lactam ring. Displays high levels of penicillinase and cephalosporinase activity as well as measurable activity with carbapenems, including imipenem and meropenem. Plays a primary role in the intrinsic resistance of mycobacteria to beta-lactam antibiotics.[UniProtKB:P9WKD3] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mycobacterium tuberculosis]] | |||
[[Category: Chikunova A]] | |||
[[Category: Radojkovic M]] | |||
[[Category: Ubbink M]] | |||
Latest revision as of 17:13, 9 July 2025
Crystal structure of I105R mutant of BlaC from Mycobacterium tuberculosis
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