9fxx: Difference between revisions
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==Influenza polymerase A C-terminal domain of PA subunit with stapled peptide inhibitor== | |||
<StructureSection load='9fxx' size='340' side='right'caption='[[9fxx]], [[Resolution|resolution]] 2.16Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9fxx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/California/07/2009(H1N1)) Influenza A virus (A/California/07/2009(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9FXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9FXX FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.16Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IG4:(~{E})-but-2-ene'>A1IG4</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9fxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9fxx OCA], [https://pdbe.org/9fxx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9fxx RCSB], [https://www.ebi.ac.uk/pdbsum/9fxx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9fxx ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/PA_I09A0 PA_I09A0] Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.[HAMAP-Rule:MF_04063] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Brynda J]] | |||
[[Category: Radilova K]] | |||
Latest revision as of 06:45, 16 July 2025
Influenza polymerase A C-terminal domain of PA subunit with stapled peptide inhibitor
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