9ip6: Difference between revisions

Latest revision as of 07:00, 16 July 2025

The complex of rice immune receptor RGA5-HMA8 with rice blast effector protein AVR1-CO39

Structural highlights

9ip6 is a 5 chain structure with sequence from Oryza sativa and Pyricularia grisea. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.63Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RGA5R_ORYSJ Disease resistance (R) protein that recognizes the AVR-Pia and AVR1-CO39 effector avirulence proteins from M.oryzae. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth. Contribution of RGA4 is required to recognize the effector avirulence proteins AVR-Pia and AVR1-CO39 from M.oryzae (PubMed:21251109, PubMed:23548743). Acts as a repressor of the RGA4-mediated cell death activation. Upon infection, recognition and binding of the AVR effectors relieve the RGA5-mediated repression and triggers the hypersensitive response (PubMed:25024433). Immune response triggered by the RGA4-RGA5 -mediated recognition of AVR1-CO39 confers resistance to X.oryzae pathovars (PubMed:27289079).^[1] ^[2] ^[3] ^[4]

References

↑ Okuyama Y, Kanzaki H, Abe A, Yoshida K, Tamiru M, Saitoh H, Fujibe T, Matsumura H, Shenton M, Galam DC, Undan J, Ito A, Sone T, Terauchi R. A multifaceted genomics approach allows the isolation of the rice Pia-blast resistance gene consisting of two adjacent NBS-LRR protein genes. Plant J. 2011 May;66(3):467-79. doi: 10.1111/j.1365-313X.2011.04502.x. Epub 2011 , Mar 7. PMID:21251109 doi:https://dx.doi.org/10.1111/j.1365-313X.2011.04502.x
↑ Cesari S, Thilliez G, Ribot C, Chalvon V, Michel C, Jauneau A, Rivas S, Alaux L, Kanzaki H, Okuyama Y, Morel JB, Fournier E, Tharreau D, Terauchi R, Kroj T. The rice resistance protein pair RGA4/RGA5 recognizes the Magnaporthe oryzae effectors AVR-Pia and AVR1-CO39 by direct binding. Plant Cell. 2013 Apr;25(4):1463-81. doi: 10.1105/tpc.112.107201. Epub 2013 Apr 2. PMID:23548743 doi:https://dx.doi.org/10.1105/tpc.112.107201
↑ Cesari S, Kanzaki H, Fujiwara T, Bernoux M, Chalvon V, Kawano Y, Shimamoto K, Dodds P, Terauchi R, Kroj T. The NB-LRR proteins RGA4 and RGA5 interact functionally and physically to confer disease resistance. EMBO J. 2014 Sep 1;33(17):1941-59. doi: 10.15252/embj.201487923. Epub 2014 Jul, 14. PMID:25024433 doi:https://dx.doi.org/10.15252/embj.201487923
↑ Hutin M, Cesari S, Chalvon V, Michel C, Tran TT, Boch J, Koebnik R, Szurek B, Kroj T. Ectopic activation of the rice NLR heteropair RGA4/RGA5 confers resistance to bacterial blight and bacterial leaf streak diseases. Plant J. 2016 Oct;88(1):43-55. doi: 10.1111/tpj.13231. Epub 2016 Aug 18. PMID:27289079 doi:https://dx.doi.org/10.1111/tpj.13231

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Okuyama Y, Kanzaki H, Abe A, Yoshida K, Tamiru M, Saitoh H, Fujibe T, Matsumura H, Shenton M, Galam DC, Undan J, Ito A, Sone T, Terauchi R. A multifaceted genomics approach allows the isolation of the rice Pia-blast resistance gene consisting of two adjacent NBS-LRR protein genes. Plant J. 2011 May;66(3):467-79. doi: 10.1111/j.1365-313X.2011.04502.x. Epub 2011 , Mar 7. PMID:21251109 doi:https://dx.doi.org/10.1111/j.1365-313X.2011.04502.x

[2] Cesari S, Thilliez G, Ribot C, Chalvon V, Michel C, Jauneau A, Rivas S, Alaux L, Kanzaki H, Okuyama Y, Morel JB, Fournier E, Tharreau D, Terauchi R, Kroj T. The rice resistance protein pair RGA4/RGA5 recognizes the Magnaporthe oryzae effectors AVR-Pia and AVR1-CO39 by direct binding. Plant Cell. 2013 Apr;25(4):1463-81. doi: 10.1105/tpc.112.107201. Epub 2013 Apr 2. PMID:23548743 doi:https://dx.doi.org/10.1105/tpc.112.107201

[3] Cesari S, Kanzaki H, Fujiwara T, Bernoux M, Chalvon V, Kawano Y, Shimamoto K, Dodds P, Terauchi R, Kroj T. The NB-LRR proteins RGA4 and RGA5 interact functionally and physically to confer disease resistance. EMBO J. 2014 Sep 1;33(17):1941-59. doi: 10.15252/embj.201487923. Epub 2014 Jul, 14. PMID:25024433 doi:https://dx.doi.org/10.15252/embj.201487923

[4] Hutin M, Cesari S, Chalvon V, Michel C, Tran TT, Boch J, Koebnik R, Szurek B, Kroj T. Ectopic activation of the rice NLR heteropair RGA4/RGA5 confers resistance to bacterial blight and bacterial leaf streak diseases. Plant J. 2016 Oct;88(1):43-55. doi: 10.1111/tpj.13231. Epub 2016 Aug 18. PMID:27289079 doi:https://dx.doi.org/10.1111/tpj.13231

[1]

[2]

[3]

[4]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9ip6 is ON HOLD  until Paper Publication
+==The complex of rice immune receptor RGA5-HMA8 with rice blast effector protein AVR1-CO39==
+<StructureSection load='9ip6' size='340' side='right'caption='[[9ip6]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9ip6]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryza_sativa Oryza sativa] and [https://en.wikipedia.org/wiki/Pyricularia_grisea Pyricularia grisea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9IP6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9IP6 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.63&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ip6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ip6 OCA], [https://pdbe.org/9ip6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ip6 RCSB], [https://www.ebi.ac.uk/pdbsum/9ip6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ip6 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RGA5R_ORYSJ RGA5R_ORYSJ] Disease resistance (R) protein that recognizes the AVR-Pia and AVR1-CO39 effector avirulence proteins from M.oryzae. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth. Contribution of RGA4 is required to recognize the effector avirulence proteins AVR-Pia and AVR1-CO39 from M.oryzae (PubMed:21251109, PubMed:23548743). Acts as a repressor of the RGA4-mediated cell death activation. Upon infection, recognition and binding of the AVR effectors relieve the RGA5-mediated repression and triggers the hypersensitive response (PubMed:25024433). Immune response triggered by the RGA4-RGA5 -mediated recognition of AVR1-CO39 confers resistance to X.oryzae pathovars (PubMed:27289079).<ref>PMID:21251109</ref> <ref>PMID:23548743</ref> <ref>PMID:25024433</ref> <ref>PMID:27289079</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Oryza sativa]]
+[[Category: Pyricularia grisea]]
+[[Category: Liu J]]
+[[Category: Zhang X]]

9ip6: Difference between revisions

Latest revision as of 07:00, 16 July 2025

The complex of rice immune receptor RGA5-HMA8 with rice blast effector protein AVR1-CO39

Structural highlights

Function

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools