8zt1: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8zt1 is ~~ON HOLD until 2026~~-06-06

==sStructure of calcium preference ATP-gated channel P2X1 in complex with BTFA==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[8zt1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZT1 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8ZT1 FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8Å</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1D8Z:3,5-bis(trifluoromethyl)aniline'>A1D8Z</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8zt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8zt1 OCA], [https://pdbe.org/8zt1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8zt1 RCSB], [https://www.ebi.ac.uk/pdbsum/8zt1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8zt1 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/P2RX1_MOUSE P2RX1_MOUSE] ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and with relatively high calcium permeability (By similarity). Furthermore, CTP functions as a weak affinity agonist for P2RX1 (By similarity). Plays a role in male fertility, bladder contraction and platelet aggregation (PubMed:10638758, PubMed:11090125, PubMed:19635923, PubMed:25150292). Specifically, plays an important role in neurogenic contraction of smooth muscle of the vas deferens, and therefore is essential for normal male reproductive function (PubMed:10638758). In addition, contributes to smooth muscle contractions of the urinary bladder (PubMed:11090125). On platelets, contributes to platelet activation and aggregation and thereby, also to thrombosis (PubMed:25150292). On neutrophils, it is involved in chemotaxis and in mitigating the activation of circulating cells (PubMed:19635923).[UniProtKB:P51575]<ref>PMID:10638758</ref> <ref>PMID:11090125</ref> <ref>PMID:19635923</ref> <ref>PMID:25150292</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Xu HE]]

[[Category: Zhang H]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8zt1 is ON HOLD  until 2026-06-06
+==sStructure of calcium preference ATP-gated channel P2X1 in complex with BTFA==
+<StructureSection load='8zt1' size='340' side='right'caption='[[8zt1]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8zt1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZT1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ZT1 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1D8Z:3,5-bis(trifluoromethyl)aniline'>A1D8Z</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8zt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8zt1 OCA], [https://pdbe.org/8zt1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8zt1 RCSB], [https://www.ebi.ac.uk/pdbsum/8zt1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8zt1 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/P2RX1_MOUSE P2RX1_MOUSE] ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and with relatively high calcium permeability (By similarity). Furthermore, CTP functions as a weak affinity agonist for P2RX1 (By similarity). Plays a role in male fertility, bladder contraction and platelet aggregation (PubMed:10638758, PubMed:11090125, PubMed:19635923, PubMed:25150292). Specifically, plays an important role in neurogenic contraction of smooth muscle of the vas deferens, and therefore is essential for normal male reproductive function (PubMed:10638758). In addition, contributes to smooth muscle contractions of the urinary bladder (PubMed:11090125). On platelets, contributes to platelet activation and aggregation and thereby, also to thrombosis (PubMed:25150292). On neutrophils, it is involved in chemotaxis and in mitigating the activation of circulating cells (PubMed:19635923).[UniProtKB:P51575]<ref>PMID:10638758</ref> <ref>PMID:11090125</ref> <ref>PMID:19635923</ref> <ref>PMID:25150292</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Xu HE]]
+[[Category: Zhang H]]