9qi6: Difference between revisions

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'''Unreleased structure'''


The entry 9qi6 is ON HOLD  until Paper Publication
==Structure of I105R BlaC from Mycobacterium tuberculosis bound to the trans-enamine adduct of clavulanic acid==
 
<StructureSection load='9qi6' size='340' side='right'caption='[[9qi6]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
Authors: Chikunova, A., Radojkovic, M., Ubbink, M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9qi6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QI6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9QI6 FirstGlance]. <br>
Description: Structure of I105R BlaC from Mycobacterium tuberculosis bound to the trans-enamine adduct of clavulanic acid
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ISS:(2E)-3-[(4-HYDROXY-2-OXOBUTYL)AMINO]PROP-2-ENAL'>ISS</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Chikunova, A]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9qi6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9qi6 OCA], [https://pdbe.org/9qi6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9qi6 RCSB], [https://www.ebi.ac.uk/pdbsum/9qi6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9qi6 ProSAT]</span></td></tr>
[[Category: Ubbink, M]]
</table>
[[Category: Radojkovic, M]]
== Function ==
[https://www.uniprot.org/uniprot/BLAC_MYCBO BLAC_MYCBO] Extended spectrum beta-lactamase (ESBL) that inactivates beta-lactam antibiotics by hydrolyzing the amide group of the beta-lactam ring. Displays high levels of penicillinase and cephalosporinase activity as well as measurable activity with carbapenems, including imipenem and meropenem. Plays a primary role in the intrinsic resistance of mycobacteria to beta-lactam antibiotics.[UniProtKB:P9WKD3]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Chikunova A]]
[[Category: Radojkovic M]]
[[Category: Ubbink M]]
Retrieved from "https://proteopedia.org/9qi6"