9qi7: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 9qi7 is ~~ON HOLD until Paper Publication~~

==Crystal structure of I105R mutant of BlaC from Mycobacterium tuberculosis in complex with avibactam==

~~Authors~~: ~~Chikunova~~, A., ~~Radojkovic~~, M., ~~Ubbink~~, M.

== Structural highlights ==

<table><tr><td colspan='2'>[[9qi7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QI7 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9QI7 FirstGlance].

~~Description~~: ~~Crystal structure~~ of ~~I105R mutant~~ of ~~BlaC from Mycobacterium tuberculosis~~ in ~~complex with avibactam~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NXL:(2S,5R)-1-FORMYL-5-[(SULFOOXY)AMINO]PIPERIDINE-2-CARBOXAMIDE'>NXL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: Chikunova, A]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9qi7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9qi7 OCA], [https://pdbe.org/9qi7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9qi7 RCSB], [https://www.ebi.ac.uk/pdbsum/9qi7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9qi7 ProSAT]</td></tr>

[[Category: ~~Ubbink,~~ M]]

</table>

[[Category: ~~Radojkovic,~~ M]]

== Function ==

[https://www.uniprot.org/uniprot/BLAC_MYCBO BLAC_MYCBO] Extended spectrum beta-lactamase (ESBL) that inactivates beta-lactam antibiotics by hydrolyzing the amide group of the beta-lactam ring. Displays high levels of penicillinase and cephalosporinase activity as well as measurable activity with carbapenems, including imipenem and meropenem. Plays a primary role in the intrinsic resistance of mycobacteria to beta-lactam antibiotics.[UniProtKB:P9WKD3]

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Mycobacterium tuberculosis]]

[[Category: Chikunova A]]

[[Category: Radojkovic M]]

[[Category: Ubbink M]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9qi7 is ON HOLD  until Paper Publication
+==Crystal structure of I105R mutant of BlaC from Mycobacterium tuberculosis in complex with avibactam==
+<StructureSection load='9qi7' size='340' side='right'caption='[[9qi7]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-Authors: Chikunova, A., Radojkovic, M., Ubbink, M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9qi7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QI7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9QI7 FirstGlance]. <br>
-Description: Crystal structure of I105R mutant of BlaC from Mycobacterium tuberculosis in complex with avibactam
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NXL:(2S,5R)-1-FORMYL-5-[(SULFOOXY)AMINO]PIPERIDINE-2-CARBOXAMIDE'>NXL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Chikunova, A]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9qi7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9qi7 OCA], [https://pdbe.org/9qi7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9qi7 RCSB], [https://www.ebi.ac.uk/pdbsum/9qi7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9qi7 ProSAT]</span></td></tr>
-[[Category: Ubbink, M]]
+</table>
-[[Category: Radojkovic, M]]
+== Function ==
+[https://www.uniprot.org/uniprot/BLAC_MYCBO BLAC_MYCBO] Extended spectrum beta-lactamase (ESBL) that inactivates beta-lactam antibiotics by hydrolyzing the amide group of the beta-lactam ring. Displays high levels of penicillinase and cephalosporinase activity as well as measurable activity with carbapenems, including imipenem and meropenem. Plays a primary role in the intrinsic resistance of mycobacteria to beta-lactam antibiotics.[UniProtKB:P9WKD3]
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mycobacterium tuberculosis]]
+[[Category: Chikunova A]]
+[[Category: Radojkovic M]]
+[[Category: Ubbink M]]