8jhg: Difference between revisions

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== Function ==
== Function ==
[https://www.uniprot.org/uniprot/KMT5B_HUMAN KMT5B_HUMAN] Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3.<ref>PMID:23720823</ref>
[https://www.uniprot.org/uniprot/H31_HUMAN H31_HUMAN]  
== References ==
<references/>
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</StructureSection>
</StructureSection>

Latest revision as of 06:14, 23 July 2025

Native SUV420H1 bound to 167-bp nucleosome

8jhg, resolution 3.58Å

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