8kfy: Difference between revisions
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==Gi bound CCR8 complex with nonpeptide agonist ZK 756326== | ==Gi bound CCR8 complex with nonpeptide agonist ZK 756326== | ||
<StructureSection load='8kfy' size='340' side='right'caption='[[8kfy]]' scene=''> | <StructureSection load='8kfy' size='340' side='right'caption='[[8kfy]], [[Resolution|resolution]] 3.06Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8KFY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8KFY FirstGlance]. <br> | <table><tr><td colspan='2'>[[8kfy]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8KFY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8KFY FirstGlance]. <br> | ||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.06Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OXF:2-[2-[4-[(3-phenoxyphenyl)methyl]piperazin-1-yl]ethoxy]ethanol'>OXF</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8kfy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8kfy OCA], [https://pdbe.org/8kfy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8kfy RCSB], [https://www.ebi.ac.uk/pdbsum/8kfy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8kfy ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8kfy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8kfy OCA], [https://pdbe.org/8kfy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8kfy RCSB], [https://www.ebi.ac.uk/pdbsum/8kfy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8kfy ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Jiang | [[Category: Synthetic construct]] | ||
[[Category: Jiang S]] | |||
[[Category: Lin X]] | |||
[[Category: Wu LJ]] | |||
[[Category: Xu F]] | |||
