9g4a: Difference between revisions
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==Structure of human SETD2 T1663M mutant in complex with SAM and H3K36M peptide== | |||
<StructureSection load='9g4a' size='340' side='right'caption='[[9g4a]], [[Resolution|resolution]] 1.65Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9g4a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9G4A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9G4A FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.653Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[Category: Haouz | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9g4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9g4a OCA], [https://pdbe.org/9g4a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9g4a RCSB], [https://www.ebi.ac.uk/pdbsum/9g4a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9g4a ProSAT]</span></td></tr> | ||
[[Category: Mechaly | </table> | ||
[[Category: Michail | == Function == | ||
[[Category: Rodrigues-Lima | [https://www.uniprot.org/uniprot/SETD2_HUMAN SETD2_HUMAN] Histone methyltransferase that methylates 'Lys-36' of histone H3. H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation. Probably plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A. Binds DNA at promoters. May also act as a transcription activator that binds to promoters. Binds to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression.<ref>PMID:16118227</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Haouz A]] | |||
[[Category: Mechaly AE]] | |||
[[Category: Michail C]] | |||
[[Category: Rodrigues-Lima F]] | |||
Latest revision as of 05:35, 30 July 2025
Structure of human SETD2 T1663M mutant in complex with SAM and H3K36M peptide
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