9ok9: Difference between revisions
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==Crystal structure of an MKP5 allosteric loop mutant, P447V, in complex with an allosteric inhibitor== | |||
<StructureSection load='9ok9' size='340' side='right'caption='[[9ok9]], [[Resolution|resolution]] 3.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9ok9]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9OK9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9OK9 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CJA:3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one'>CJA</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ok9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ok9 OCA], [https://pdbe.org/9ok9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ok9 RCSB], [https://www.ebi.ac.uk/pdbsum/9ok9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ok9 ProSAT]</span></td></tr> | ||
[[Category: Bennett | </table> | ||
[[Category: Lolis | == Function == | ||
[https://www.uniprot.org/uniprot/DUS10_HUMAN DUS10_HUMAN] Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily.<ref>PMID:22375048</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Bennett AM]] | |||
[[Category: Lolis E]] | |||
[[Category: Manjula R]] | |||
Latest revision as of 05:48, 30 July 2025
Crystal structure of an MKP5 allosteric loop mutant, P447V, in complex with an allosteric inhibitor
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