9k3k: Difference between revisions

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'''Unreleased structure'''


The entry 9k3k is ON HOLD  until Paper Publication
==Cryo-EM structure of the unliganded human melanocortin receptor 4 (MC4R)-Gs complex==
 
<StructureSection load='9k3k' size='340' side='right'caption='[[9k3k]], [[Resolution|resolution]] 3.12&Aring;' scene=''>
Authors: Feng, W.B., Zhou, Q.T., Zheng, C., Yang, D.H., Wang, M.W.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9k3k]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9K3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9K3K FirstGlance]. <br>
Description: Cryo-EM structure of the unliganded human melanocortin receptor 4 (MC4R)-Gs complex
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.12&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9k3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9k3k OCA], [https://pdbe.org/9k3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9k3k RCSB], [https://www.ebi.ac.uk/pdbsum/9k3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9k3k ProSAT]</span></td></tr>
[[Category: Feng, W.B]]
</table>
[[Category: Wang, M.W]]
== Disease ==
[[Category: Yang, D.H]]
[https://www.uniprot.org/uniprot/MC4R_HUMAN MC4R_HUMAN] Obesity due to melanocortin 4 receptor deficiency. The disease is caused by mutations affecting the gene represented in this entry.
[[Category: Zhou, Q.T]]
== Function ==
[[Category: Zheng, C]]
[https://www.uniprot.org/uniprot/MC4R_HUMAN MC4R_HUMAN] Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).<ref>PMID:12646665</ref> <ref>PMID:25163632</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Feng WB]]
[[Category: Wang MW]]
[[Category: Yang DH]]
[[Category: Zheng C]]
[[Category: Zhou QT]]
Retrieved from "https://proteopedia.org/9k3k"