9noy: Difference between revisions
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==Human TAS1R2 transmembrane domains from the TAS1R2-TM-G protein complex== | |||
<StructureSection load='9noy' size='340' side='right'caption='[[9noy]], [[Resolution|resolution]] 3.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9noy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NOY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NOY FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9noy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9noy OCA], [https://pdbe.org/9noy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9noy RCSB], [https://www.ebi.ac.uk/pdbsum/9noy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9noy ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TS1R2_HUMAN TS1R2_HUMAN] Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
In humans, the detection and ultimately the perception of sweetness begin in the oral cavity, where taste receptor cells (TRCs) dedicated to sweet-sensing interact with sugars, artificial sweeteners, and other sweet-tasting chemicals. Human sweet TRCs express on their cell surface a sweet receptor that initiates the cascade of signaling events responsible for our strong attraction to sweet stimuli. Here, we describe the cryo-electron microscopy (cryo-EM) structure of the human sweet receptor bound to two of the most widely used artificial sweeteners-sucralose and aspartame. Our results reveal the structural basis for sweet detection, provide insights into how a single receptor mediates all our responses to such a wide range of sweet-tasting compounds, and open up unique possibilities for designing a generation of taste modulators informed by the structure of the human receptor. | |||
The structure of human sweetness.,Juen Z, Lu Z, Yu R, Chang AN, Wang B, Fitzpatrick AWP, Zuker CS Cell. 2025 May 2:S0092-8674(25)00456-8. doi: 10.1016/j.cell.2025.04.021. PMID:40339580<ref>PMID:40339580</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 9noy" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Chang AN]] | |||
[[Category: Fitzpatrick AWP]] | |||
[[Category: Juen Z]] | |||
[[Category: Lu Z]] | |||
[[Category: Wang B]] | |||
[[Category: Yu R]] | |||
[[Category: Zuker CS]] | |||
Latest revision as of 06:06, 6 August 2025
Human TAS1R2 transmembrane domains from the TAS1R2-TM-G protein complex
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