9ncv: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9ncv is ~~ON HOLD until Paper Publication~~

==Crystal Structure of WDR5 in complex with Triazole-Based Inhibitors==

~~Authors~~: ~~Goins~~, C.M., ~~Stauffer~~, S.R.

== Structural highlights ==

<table><tr><td colspan='2'>[[9ncv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NCV OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9NCV FirstGlance].

~~Description~~: ~~Crystal Structure~~ of ~~WDR5~~ in complex ~~with Triazole-Based Inhibitors~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BW8:6-[1-ethyl-3-(trifluoromethyl)pyrazol-4-yl]-3-[(4-fluoranyl-3-methyl-phenyl)methyl]-8-[(2-methylimidazol-1-yl)methyl]-4,5-dihydrobenzo[e]benzotriazole'>A1BW8</scene></td></tr>

[[Category: ~~Stauffer, S.R~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9ncv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ncv OCA], [https://pdbe.org/9ncv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ncv RCSB], [https://www.ebi.ac.uk/pdbsum/9ncv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ncv ProSAT]</td></tr>

[[Category: ~~Goins, C.M~~]]

</table>

== Function ==

[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Goins CM]]

[[Category: Stauffer SR]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9ncv is ON HOLD  until Paper Publication
+==Crystal Structure of WDR5 in complex with Triazole-Based Inhibitors==
+<StructureSection load='9ncv' size='340' side='right'caption='[[9ncv]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
-Authors: Goins, C.M., Stauffer, S.R.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9ncv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NCV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NCV FirstGlance]. <br>
-Description: Crystal Structure of WDR5 in complex with Triazole-Based Inhibitors
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BW8:6-[1-ethyl-3-(trifluoromethyl)pyrazol-4-yl]-3-[(4-fluoranyl-3-methyl-phenyl)methyl]-8-[(2-methylimidazol-1-yl)methyl]-4,5-dihydrobenzo[e]benzotriazole'>A1BW8</scene></td></tr>
-[[Category: Stauffer, S.R]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ncv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ncv OCA], [https://pdbe.org/9ncv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ncv RCSB], [https://www.ebi.ac.uk/pdbsum/9ncv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ncv ProSAT]</span></td></tr>
-[[Category: Goins, C.M]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Goins CM]]
+[[Category: Stauffer SR]]