9ibe: Difference between revisions
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==D-2-hydroxyacid dehydrogenase (D2HDH) from Haloferax mediterranei in complex with potassium, 2-ketohexanoic acid, NADP+ and chloride== | |||
<StructureSection load='9ibe' size='340' side='right'caption='[[9ibe]], [[Resolution|resolution]] 1.26Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9ibe]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Haloferax_mediterranei Haloferax mediterranei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9IBE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9IBE FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.26Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7N5:2-oxidanylidenehexanoic+acid'>7N5</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ibe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ibe OCA], [https://pdbe.org/9ibe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ibe RCSB], [https://www.ebi.ac.uk/pdbsum/9ibe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ibe ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DDH_HALMT DDH_HALMT] Catalyzes the stereospecific NAD(P)H-dependent reduction of 2-ketocarboxylic acids into the corresponding D-2-hydroxycarboxylic acids. Can use both NADPH or NADH as reductant, displaying a marked preference for NADPH over NADH. Shows a broad substrate specificity, although it displays a marked preference for the 2-ketocarboxylic acids having an unbranched chain of 4-5 carbon atoms.<ref>PMID:17049749</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Haloferax mediterranei]] | |||
[[Category: Large Structures]] | |||
[[Category: Baker PJ]] | |||
[[Category: Barrett JR]] | |||
[[Category: Bisson C]] | |||
[[Category: Dakhil AAAB]] | |||
[[Category: Domenech J]] | |||
[[Category: Ferrer J]] | |||
[[Category: Pramanpol N]] | |||
[[Category: Rice DW]] | |||
Latest revision as of 06:16, 20 August 2025
D-2-hydroxyacid dehydrogenase (D2HDH) from Haloferax mediterranei in complex with potassium, 2-ketohexanoic acid, NADP+ and chloride
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