9ml3: Difference between revisions

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'''Unreleased structure'''


The entry 9ml3 is ON HOLD  until Paper Publication
==B25M05 Fab bound to HPV16 L1 pentamer==
 
<StructureSection load='9ml3' size='340' side='right'caption='[[9ml3]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
Authors: Hurlburt, N.K., Singh, S., Rodarte, J.V., Pancera, M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9ml3]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ML3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ML3 FirstGlance]. <br>
Description: B25M05 Fab bound to HPV16 L1 pentamer
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ml3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ml3 OCA], [https://pdbe.org/9ml3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ml3 RCSB], [https://www.ebi.ac.uk/pdbsum/9ml3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ml3 ProSAT]</span></td></tr>
[[Category: Singh, S]]
</table>
[[Category: Rodarte, J.V]]
== Function ==
[[Category: Hurlburt, N.K]]
[https://www.uniprot.org/uniprot/A0A451ER69_HPV16 A0A451ER69_HPV16] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[RuleBase:RU361248]
[[Category: Pancera, M]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Human papillomavirus type 16]]
[[Category: Large Structures]]
[[Category: Hurlburt NK]]
[[Category: Pancera M]]
[[Category: Rodarte JV]]
[[Category: Singh S]]
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